Acetylcholinesterase activity in type 2 diabetes mellitus

Thakur, Rajesh Kumar and Mishra, Manoj and Sharma, Stuti and Mohan, Sheetal and Gyawali, Prabin and Mukherjee, Madhurima and Prabhu, Krishnananda and Rao, Anjali (2008) Acetylcholinesterase activity in type 2 diabetes mellitus. In: International Conference on"Free Radicals and Natural Products in Health” , 14-16 Feb 2008, Rajasthan, Jaipur, India. (Submitted)

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Introduction: Changes in the activity of acetylcholinesterase (AChE) have been reported in diabetes mellitus. Studies showed drugs which stimulated release of acetylcholine from nerve terminals in rats so as to stimulate muscarinic M (3) receptors activity located in the pancreatic cells for the secretion of insulin, which lowered plasma glucose. Acetylcholinesterase activity was significantly lower in type 2 diabetic patients than in normal controls and in vitro insulin treatment restored this activity to normal levels. Hypothesis: Acetylcholine may be having a role in insulin release in humans and there may be a role for acetylcholinesterase inhibitors in treatment of diabetes. Materials and methods: RBC acetylcholinesterase levels were compared between diabetic male patients aged between 45 -60 years on oral hypoglycemic drugs attending the out patient department of Kasturba Medical College Hospital and equal number of age and sex matched healthy controls. Results: RBC acetylcholinesterase in normal was 106.7 (83.1, 144.8) IU/gr Hb/Ltr and in diabetic patients was 99.9(56.1, 138.7) IU/gr Hb/Ltr[median and inter quartile range]. This shows there was a decrease in RBC acetylcholinesterase levels in patients as compared to controls. Conclusion: Our results show that acetylcholinesterase may serve as a marker of diabetes and also may have a role as therapeutic target as studies have shown a role for acetylcholine in insulin release. We will continue our study to further substantiate our findings.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 03 Apr 2014 04:53
Last Modified: 03 Apr 2014 04:53

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