Phosphodiesterase activity in intrauterine growth restriction

Sharma, Stuti and Mohan, Sheethal and Prabhu, Krishnananda and Rao, Anjali (2008) Phosphodiesterase activity in intrauterine growth restriction. In: 35th ACBICON, 19-21 Dec 2008, Kolkata. (Submitted)

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Abstract

Introduction: Intrauterine growth restriction (IUGR) is a term used to describe a condition in which the fetus is smaller than expected for the number of weeks of pregnancy. This may occur when the fetus does not receive the necessary nutrients and oxygen needed for growth and development of organs and tissues because of uteroplacental insufficiency and fetoplacental hypoxemia. Cyclic nucleotides cyclic guanosine monophosphate (cGMP) dilates intact tonic spiral arteries and counters hypoxemic fetoplacental vasoconstriction and improves intervillous and intravillous perfusion. Hypothesis: Cyclic nucleotide phosphodiesterases (PDEs) are with multiple regulatory properties and wide tissue distribution which causes breakdown cAMP and cGMP may have a role in maintaining proper fetoplacental circulation and IUGR. Materials and methods: Plasma phosphodiesterase were measured in ultrasonography proven IUGR cases attending Kasturba Medical College Hospital, Manipal and their levels were compared with that of normal pregnant women of dame gestational period. Results: We observed a significant low values of phosphodiesterase levels in IUGR patients as compared to normal pregnant woman (p< 0.017). Conclusion: Phosphodiesterase may have a role in maintaining fetoplacental circulation.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 05 Apr 2014 04:08
Last Modified: 05 Apr 2014 04:08
URI: http://eprints.manipal.edu/id/eprint/139312

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