Chianeh, Yousef Rezaei and Prabhu, Krishnananda and Rashmi, M (2012) Estimation of protein thiols in saliva of oral cancer patients. In: The International Symposium SFRR, 12-14 Jan 2012, Kolkata. (Submitted)

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Abstract

Introduction:Oral squamous cell carcinoma (OSCC) is one of the most common malignancies recognized nowadays, and represents a public health problem. Several studies have identified potential biomarkers of OSCC progression and prognosis Overproduction of lipid peroxidation byproducts and disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases including oral cancer. The –SH group (reduced thiols) bound to proteins (protein thiols) play a major role in maintaining the antioxidant status of the body. Aim: To estimate the activity of protein thiol in saliva of oral cancer patients before definitive treatment and compare that with controls. Material and Methods: Institutional Ethics Committee gave permission to undertake this study. After obtaining prior consent, unstimulated saliva (5 ml) was taken with aseptic precautions from biopsy proven oral cancer patients and age & sex matched healthy controls in disposable plastic containers. Resultsand Discussion:The mean values of salivary protein thiols were significantly decreased (p ) among oral cancer patients as compared to that of controls. This indicates salivary thiols can be a potential prognostic marker of oral cancer. Conclusion:Saliva can be a noninvasive tool in management of oral cancer.

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