Correlation of adenosine deaminase activity in cerebrospinal fluid with CD4 count in HIV positive patients suffering from tuberculous meningitis

Prabhu, Krishnananda and Shenoy, Vijetha Belle (2013) Correlation of adenosine deaminase activity in cerebrospinal fluid with CD4 count in HIV positive patients suffering from tuberculous meningitis. In: International Conference on Forensic Sciences, 08-09 Jul 2013, London, UK. (Submitted)

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Abstract

Background: Adenosine deaminase (ADA) is a "key" enzyme in purine metabolism, promoting the deamination of adenosine, an important anti-inflammatory molecule. An increase in serum ADA activity has been demonstrated in several inflammatory conditions. Isoforms of the ADA are capable of binding to glycoprotein CD26 and adenosine receptors leading to T cell activation. Thus, the activity of ADA has been associated with the functionalism and replication of the T lymphocytes. Studies have shown that ADA activity changes in diseases characterized by altered cell-mediated immunity. Several studies have revealed increased serum levels of ADA with evolution of human immunodeficiency virus (HIV) infection. Hence, this study was carried out to assess whether there was a correlation between CD4 count and ADA levels in the cerebrospinal fluid in HIV positive patients with tubercular meningitis. Material and methods: The study was approved by Institutional Ethics committee. CSF ADA was measured in pateints admitted to Kasturba Hospital, Manipal with tubercular or non- tubercularmeningitis. Total of 22subjects (non- tubercular meningitis = 12, tubercular meningitis = 10) participated in this study. Results and conclusion:ADA values in CSF increased significantly in cases as compared to that of controls (p = 0.001). This indicates there may be a role for CSF ADA in differentiating tuberculous from non-tuberculous meningitis.ADA values showed a significant inverse correlation with CD4 count in HIV positive patients with tubercular meningitis (p = 0.054; r = - 0.624) indicating a role for disease prognosis.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 07 Apr 2014 04:40
Last Modified: 10 Mar 2017 09:33
URI: http://eprints.manipal.edu/id/eprint/139325

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