Hyperamylasemia as an indicator of Acute Pancreatitis in Severe Leptospirosis- A preliminary study

*, Abul Fazil and *, Sheetal Raj and Verma, Aditya and Rao, Jagadish Padubidri (2014) Hyperamylasemia as an indicator of Acute Pancreatitis in Severe Leptospirosis- A preliminary study. Journal of Pharmaceutical and Biomedical Sciences, 04 (04). pp. 273-278. ISSN 2230 – 7885

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Background/ objective: Leptospirosis is a spirochetal bacterial infection of great public health importance. Acute pancreatitis is an uncommon gastrointestinal manifestation of leptospirosis. The aims and objective of this study was to find the incidence of hyperamylasemia in cases of severe leptospirosis and to correlate the incidence of hyperamylasemia with acute pancreatitis among patients with severe leptospirosis. Methods: All patients who were positive for IgM ELISA test (IgM ELISA > 11 panbiounits was considered positive for leptospirosis) and had features suggestive of severe leptospirosis or Weil’s disease were included in the study. Serum amylase levels were assessed in all patients, included in the study. An ultrasound of the abdomen was done to objectively confirm or refute the presence of acute pancreatitis in all patients included in the study. Results: The study included 25 cases diagnosed of Severe Leptospirosis. 24 out of 25 cases [96 %] had renal failure. All the cases [100%] had deranged liver function tests. 17 out of the 25 [68%] cases had hyperamylasemia. Almost all patients showed evidence of multi organ dysfunction in the form of deranged renal function or hepatic dysfunction or both. Out of the total 25 cases included in the study, 17 cases[68%] showed elevated levels of serum amylase. Conclusions: It is evident from this study that despite of low reporting, the dangerous complication of acute pancreatitis is not so rare among patients with severe leptospirosis. Hyperamylasemia is commonly seen with an incidence of 68% among these patients. Our study shows that, threefold rise of serum amylase level remains a very specific and cost effective test for detection of acute pancreatitis in patients with severe leptospirosis.

Item Type: Article
Uncontrolled Keywords: Leptospirosis; serum amylase; hyperamylasemia; acute pancreatitis.
Subjects: Medicine > KMC Mangalore > Forensic Medicine
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 09 Apr 2014 05:14
Last Modified: 09 Apr 2014 05:14
URI: http://eprints.manipal.edu/id/eprint/139339

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