Evaluation of Anti-inflammatory Activity of Alcoholic Extract of Leaves of Leucas Aspera in Albino Rats

Patil, Navin A and Bairy, KL and Parida, Amrita and Malalur, Chaithanya and Kotian, Rahul P (2014) Evaluation of Anti-inflammatory Activity of Alcoholic Extract of Leaves of Leucas Aspera in Albino Rats. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (2). pp. 715-719. ISSN 0975 - 1491

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Abstract

Objective: Alcoholic extract of leaves of Leucas Aspera was tested for anti-inflammatory activity in animal models. Methods: Three doses, 100 mg/kg, 200 mg/kg and 4 00 mg/kg of the plant e xtract prepared as a suspension in 1% tween 80 in normal saline. The control group received only Tween 80 (2%, v/v) orally . Acute and sub - acute inflammatory activities were studied in rats by ca rrageenan induced paw edema and cotton pellet induced granuloma models respectively. In both models, the standard drug used was diclofenac 15 0 mg/kg. Results: All the three test doses (100mg/kg, 200mg/kg,400mg/kg) at different time intervals(0 - 4 hours) did exhibit anti- nflammatory activity in both models ie. Carrageenan model and cotton pellet granuloma model in comparison to control.The test dose of 400mg/kg of leucas aspera produced a percentage inhibition of 60.64%which was comparable to standard drug Diclofenac which produced a percentage inhibition of 60.70% in carrageenan model, whilst the percentage inhibition by cotton pellet method for standard drug was 60.27% and for three different doses of test (100,200,400mg/kg) was 50.85%,57.63%, and 58.42% respectively. Conclusion: Leucas Aspera possesses significant anti- inflammatory activity with p value (0.0001).

Item Type: Article
Uncontrolled Keywords: Anti-inflammatory activity; Leucas Aspera; Carrageenan induced paw edema; Cotton wool pellet granuloma; NSAIDs(Non-steroidal antiinflamatory drugs)
Subjects: Allied Health > MCOAHS Manipal > Medical Imaging Tech
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 23 Apr 2014 04:20
Last Modified: 30 Jul 2015 11:01
URI: http://eprints.manipal.edu/id/eprint/139425

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