Synthesis, antimicrobial and docking studies of novel benzotriazole derivatives

Kumar, Pramod B and Kini, Suvarna G and Mubeen, Muhammad (2014) Synthesis, antimicrobial and docking studies of novel benzotriazole derivatives. International Journal of Pharma and Bio Sciences, 5 (2). pp. 35-42. ISSN 0975-6299

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Abstract

In view of the biological and clinical importance of Benzotriazole compounds, some new derivatives were synthesized and characterized on the basis of analytical and spectral data. All the new compounds were evaluated at 500μg/ml, 250μg/ml and 100μg/ml for the antibacterial and antifungal activity. Some of the compounds showed moderate to good antimicrobial activity against gram positive and gram negative bacteria. Compound BT1 was found to be of potent activity against Candida albicans at a concentration of 500μg/ml. Docking studies of the synthesized compounds were carried out with the help of VLife MDS 4.2 software using GRIP batch docking method to validate the results obtained in in-vitro studies.

Item Type: Article
Uncontrolled Keywords: Antibacterial; antifungal; docking; benzotriazole; candida albicans.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 25 Apr 2014 06:23
Last Modified: 25 Apr 2014 06:23
URI: http://eprints.manipal.edu/id/eprint/139446

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