Formulation and evaluation of multiparticulate systems of rifampicin and isoniazid with improved rifampicin stability

Krishna, Vamshi T and Reddy, Sreenivasa M (2014) Formulation and evaluation of multiparticulate systems of rifampicin and isoniazid with improved rifampicin stability. nternational Journal of Pharmacy and Pharmaceutical Sciences, 6 (2). pp. 386-388. ISSN 0975-1491

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FORMULATION AND EVALUATION OF MULTIPARTICULATE SYSTEMS OF RIFAMPICIN AND ISONIAZID WITH IMPROVED RIFAMPICIN STABILITY.pdf - Published Version
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Abstract

Context: One of the main reasons for the development of resistance to Tuberculosis is the drug-drug interactions as the therapy includes combination of various drugs. One such commonly reported interaction is between Rifampicin and Isoniazid, the two extensively used drugs in the treatment of Tuberculosis in the stomach pHleading to the poor stability and bioavailability of Rifampicin. Objective: The aim of the present study is to formulate and evaluate pellets of Rifampicin and Isoniazid with improved Rifampicin stability in in vitro conditions. Methods: Two different capsule formulations of these drugs were prepared. Formulation-I contains immediate release uncoated pellets of Rifampicin and Isoniazid. Formulation-IIcontains immediate release pellets of Rifampicin and enteric coated pellets of Isoniazid. These pellets were evaluated for various physicochemical parameters. Enteric coating was mainly done to prevent the release of Isoniazid in acidic medium and to improve the stability of Rifampicin by preventing their interaction in stomach. Dissolution studies for both these formulations were performed and the cumulative percentage drug release for Rifampicin was calculated. Results: The cumulative percentage drug release for Rifampicin was found to be around 81% in formulation-I whereas it has been increased to 92% in formulation-II. Conclusion: This study proves that Rifampicin interacts with Isoniazid and undergoes degradation to a significant extent in acidic medium. This interaction and degradation can be reduced and the stabilityof Rifampicin can be enhanced by formulating Isoniazid as enteric coated pellets.

Item Type: Article
Uncontrolled Keywords: Enteric coating; Pellets; Drug-drug interactions.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 25 Apr 2014 10:57
Last Modified: 25 Apr 2014 10:57
URI: http://eprints.manipal.edu/id/eprint/139448

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