Efficacy And Safety of Sauropus Androgynous in the Treatment of Aphthous Stomatitis- A Placebo Controlled Double Blind Trial

Shenoy, Ashok K and Chowta, Mukta N and Shenoy, Nandita and Adhikari, Prabha (2014) Efficacy And Safety of Sauropus Androgynous in the Treatment of Aphthous Stomatitis- A Placebo Controlled Double Blind Trial. Journal of Medical Science and Clinical Research, 2 (5). pp. 1187-1193. ISSN (e)-2347-176x

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Recurrent aphthous stomatitis (RAS) is a common inflammatory condition of unknown aetiology, although a variety of predisposing and other risk factors have been identified. Manifestation of the disease can range from mild to severe and, in extreme cases, even hinder a person’s ability to eat, thereby compromising the patient s nutritional status1. The cause of RAS is unknown, although several factors are suspected including genetics, stress, nutritional deficiencies, diet, hormonal changes, and immunological disorders.2,3 Due to its varied etiology, it is difficult to find a definitive cure and hence the current management protocol is aimed towards ameliorating the symptoms. Sauropus androgynous (SA) is a member of the family Phyllanthaceae. The aim of the present study was to carry out randomized, placebo controlled investigation into the efficacy of Sauropus androgynous leaves in patients wit h RAS One hundred adult patients who presented with RAU and healthy otherwise were included in the study. A clinical diagnosis of RAS was made based on the presence of painful ulcers on an erythematous base with duration less than 48 hours. Patients were excluded if they presented with any underlying systemic disorder, suffering from an uncorrected dietary defect, or had a history of probable sensitivity to mouthwash or toothpaste. Informed consent was obtained and general history, history with reference to ulcer number, duration, degree of pain. Past history of similar ulcers, time taken to heal was recorded. SA in both forms offered advantages over steroids in our study and is safe in all patients including infants and pregnant women, in whom there may be reluctance to use steroids.

Item Type: Article
Subjects: Dentistry > MCODS Mangalore > Oral Medicine and Radiology
Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 04 Jun 2014 07:38
Last Modified: 04 Jun 2014 07:38
URI: http://eprints.manipal.edu/id/eprint/139651

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