Kotian, Prem and Salian, Preetham Raj V and Nahar, Vivek and Pinto, Deepak and Shetty, Suresh Kumar B and Kotian, MS (2014) Multiple Myeloma – A prospective study of various clinical and laboratorial parameters in relationship to survival and treatment. International Journal of A J Institute of Medical Sciences, 3 (1). pp. 52-64.

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Abstract

A prospective study of presenting features of Sixty-two cases of multiple myeloma were analyzed in order to know the common modes of presentation and its laboratory and radiological features along with the prognostic impacts of easily available laboratory parameters, which can then evaluate the length of survival at presentation and guide towards appropriate treatment interventions. Survival was calculated using Kaplan-Meier estimates with SPSS software. The most common presenting clinical features were bone pain (83.9 %), pathological fractures (53.2%), weakness and fatigue (20%). Others include fever, bleeding diatheses, and infections. 34% of patients had renal failure while one case of classical POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein and Skin changes) was present. Lytic bone lesions were seen in 60 out of 62 patients on skeletal survey. Median survival was 18 months. Increasing age, low haemoglobin, platelet and serum albumin levels, elevated Erythrocyte Sedimentation Rate, blood urea, serum creatinine and serum calcium concentration, presence of more than 30% plasma cells in the bone marrow and Bence Jones Proteinuria were associated with short survival. However in this study , statistically significant association with the survival was found only with Bence Jones Proteinuria, blood urea, serum creatinine and serum calcium concentrations.

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