Synthesis, characterization, and preclinical evaluation of new thiazolidin-4-Ones substituted with p-Chlorophenoxy acetic acid and clofibric acid against insulin resistance and metabolic disorder

Gowdra, Vasantharaju S and Mudgal, Jayesh and Bansal, Punit and Nayak, Pawan G and Reddy, Seethappa A Manohara and Shenoy, Gautham G and Valiathan, Manna and Chamallamudi, Mallikarjuna Rao and Nampurath, Gopalan Kutty (2014) Synthesis, characterization, and preclinical evaluation of new thiazolidin-4-Ones substituted with p-Chlorophenoxy acetic acid and clofibric acid against insulin resistance and metabolic disorder. BioMed Research International, 2014. pp. 1-14.

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Abstract

We synthesized twenty thiazolidin-4-one derivatives, which were then characterized by standard chromatographic and spectroscopic methods. From the in vitro glucose uptake assay, two compounds behaved as insulin sensitizers, where they enhanced glucose uptake in isolated rat diaphragm. In high-carbohydrate diet-induced insulin resistant mice, these two thiazolidin-4-ones attenuated hyperglycemia, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia, and glucose intolerance.They raised the plasma leptin but did not reverse the diabetes-induced hypoadiponectinemia. Additionally, compound 3a reduced adiposity.The test compounds were also able to reverse the disturbed liver antioxidant milieu. To conclude, these two novel thiazolidin-4-ones modulatedmultiplemechanisms involved in metabolic disorders, reversing insulin resistance and thus preventing the development of type-2 diabetes.

Item Type: Article
Subjects: Medicine > KMC Manipal > Pathology
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 07 Jun 2014 04:36
Last Modified: 07 Jun 2014 04:36
URI: http://eprints.manipal.edu/id/eprint/139674

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