Antioxidant and antibacterial activity of some newer flavone derivatives

Jayashree, BS and Chaturvedi, Piyush and Venkatachalam, H (2013) Antioxidant and antibacterial activity of some newer flavone derivatives. Indian Journal of Applied Research, 3 (10). pp. 1-3. ISSN 2249 - 555X

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Synthesis of novel chalcone from the 2-hydroxy acetophenone and 5-nitro thiophene carboxyaldehyde with various substitutions are described. They were evaluated for their antioxidant and antibacterial activity against Gram positive and Gram negative bacteria. The test compound JPC-9 is one of the test compounds with highest IC50 values by DPPH and ABTS method and has shown log P value at 1.76 against standard ascorbic acid. Compounds such as JPC-3, JPC-4, JPC-5, JPC-6, JPC-9, JPC-10, and JPC-13 were found to have shown zone of inhibition against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa and Escherichia coli at the range 31.25-250 μg/50μL when compared to that of the standard ciprofloxacin at 25μg/50μL.

Item Type: Article
Uncontrolled Keywords: Anti-microbial; antioxidant; flavones; activity.
Subjects: Health Sciences > KMCIC
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 09 Jun 2014 04:13
Last Modified: 09 Jun 2014 04:13

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