Iminoflavones Combat 1,2-Dimethyl Hydrazine-Induced Aberrant Crypt Foci Development in Colon Cancer

Prasad, Ganga V and Kawade, Shishir and Jayashree, BS and Reddy, Neetinkumar D and Francis, Albi and Nayak, Pawan G and Kishore, Anoop and Nandakumar, K and Rao, Mallikarjuna C and Shenoy, Rekha R (2014) Iminoflavones Combat 1,2-Dimethyl Hydrazine-Induced Aberrant Crypt Foci Development in Colon Cancer. BioMed Research International, 2014. pp. 1-8.

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Abstract

The aim of the present study was to evaluate the antitumor potential of iminoflavones in in vitro and in vivo anticancer models. Preliminary screening in various cancer cell lines revealed four potential iminoflavones out of which IMF-8 was taken based on its activity against colon cancer cells. This was further confirmed by observing the nuclear changes in the cells by AO/EB and Hoechst 33342 staining studies. In vivo activity was assessed by dimethyl hydrazine-(DMH-) induced colon cancer model in rats. Animals were administered DMH (20mg/kg, b.w. for 10 weeks and 30mg/kg b.w., i.p. for 10 weeks) and were supplemented with (IMF-8) iminoflavone-8 (200mg/kg, p.o. for 14 days). Results showed that DMH induced 100% aberrant crypt foci (ACF) and polyps which were significantly reduced in the IMF-8 treated group. IMF-8 significantly increased the catalase and GSHlevels whereas it reduced the TNF-

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 12 Jun 2014 04:24
Last Modified: 05 Nov 2016 15:02
URI: http://eprints.manipal.edu/id/eprint/139728

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