Effect of fluoride varnish and chlorhexidine–thymol varnish on mutans streptococci levels in human dental plaque: a double-blinded randomized controlled trial

Paul, Sanchit and *, Suprabha BS and *, Ethel Suman and Shenoy, Ramya and Rao, Arathi (2013) Effect of fluoride varnish and chlorhexidine–thymol varnish on mutans streptococci levels in human dental plaque: a double-blinded randomized controlled trial. International Journal of Pediatric Dentistry. pp. 1-10.

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Abstract

Background: Recent systematic reviews on clinicaltrials comparing the efficacy of chlorhexidine andfluoride varnish found that the evidence wasinconclusive and further well-conducted randomizedcontrolled clinical trials were advocated. Aim: To compare the effect of fluoride varnish (F)and Chlorhexidine–thymol varnish (CHX/T) withintensive application regimen on mutans streptococci (MS) levels in human dental plaque. Design: Seventy-five subjects between 6 and10 years of age were allocated into three groups:Group 1-F varnish (n = 29); Group 2-CHX/T varnish(n = 29); Group 3-placebo varnish (n = 17) bystratified block randomization. After baseline plaquesamples were obtained, varnish applicationwas applied and repeated at an interval of 3 daysin each group. Plaque samples were repeated at 48 h, 1 month, and 3 months. The samples werespread over mitis-salivarius-bacitracin (MSB) culturemedia, and the colony-forming units per ml (CFU) were measured. Results: In both Groups 1 and 2, Wilcoxonmatched-pairs signed-rank test revealed significantdifferences in log CFU values of MS between baseline and 48 h, baseline and 1 month but no significantdifference between baseline and3 months. An intergroup comparison at differenttime intervals showed that the difference betweenthree groups was statistically insignificant. Conclusion: F varnish and CHX/T varnish, with anintensive regimen application have equivocaleffect on MS levels in dental plaque.

Item Type: Article
Subjects: Dentistry > MCODS Mangalore > Public Health Dentistry
Dentistry > MCODS Mangalore > Pedodontics
Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 13 Jun 2014 09:51
Last Modified: 13 Jun 2014 09:51
URI: http://eprints.manipal.edu/id/eprint/139766

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