Role of renoprotective therapy on antioxidant status in children with nephrotic syndrome

Prabhu, Krishnananda and Malik, Rimshida and Pai, Priya and Gayathri, S and Rao, Anjali and Bhaskaranand, Nalini (2014) Role of renoprotective therapy on antioxidant status in children with nephrotic syndrome. Journal of international academic research for multidisciplinary, 2 (4). pp. 576-581. ISSN 2320-5083

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Abstract

To prove that reactive oxygen species play a major role in nephrotic syndrome (NS) where in it could have an influence on the effectiveness of renoprotective therapy (RPT) in nephrotic children. Plasma protein thiols and ferric reducing antioxidant power of plasma (FRAP) were estimated in 30 children with NS, before the onset of RPT and also in 19 children in relapse as well as in 30 healthy controls. These parameters were also estimated in 6 children twice that is, before starting RPT and after a period of four years of RPT. There was a significant decrease in plasma protein thiol values in pre – RPT and children in relapse when compared to controls. No significant difference was observed in plasma FRAP levels in these groups. However, in 6 children after four years of RPT treatment, a noticeable decrease in plasma protein thiol and a siginificant decrease in FRAP levels was observed when compared to their initial values. Hence, this study indicates that the antioxidant status of children with NS probably has a role to play in their prognosis. A comparison of antioxidant status in pre - and post -RPT children further justifies this role as after therapy the turnover of the antioxidants decreases due to less demand with improvement in the clinical condition.

Item Type: Article
Uncontrolled Keywords: Nephrotic syndrome; plasma; protein thiols; renoprotective therapy; total antioxidant power.
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Paediatrics
Depositing User: KMC Manipal
Date Deposited: 16 Jun 2014 04:55
Last Modified: 16 Jun 2014 04:55
URI: http://eprints.manipal.edu/id/eprint/139786

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