Evaluation of Antidiabetic Activity of Vitis vinifera Stem Bark

Rai, Padmalatha S (2012) Evaluation of Antidiabetic Activity of Vitis vinifera Stem Bark. Journal of Pharmacy Research , 5 (11). pp. 5239-5242. ISSN 0974-6943

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Abstract

In the present study the antidiabetic activities of the chloroform and ethanolic extract of Vitis vinifera L. stem bark were investigated and also estimated the plasma levels of different lipids and antioxidant enzyme activity in the serum of control and experimental groups of rats. Blood glucose levels, estimated in 16 h fasting diabetic rats (FBG) was reduced significantly upon treatment with the stem bark extracts. The levels of Total serum cholesterol (TC), Low density lipoprotein cholesterol (LDLc), Very Low density lipoprotein cholesterol (VLDLc) and Triglycerides (TG) were significantly (p < 0.05) increased, whereas the High density lipoprotein cholesterol (HDL-c) was markedly (p < 0.05) decreased in rats induced with alloxan when compared with control rats. In diabetes induced group of rats, there was a decreased superoxide dismutase (SOD), catalase and peroxidase and increased lipid peroxidation. Pretreatment with plant extracts improved the SOD, catalase and peroxidase levels significantly and reduced lipid peroxidation comparable to standard drug treated group of animals. Chloroform and ethanol extracts could effectively normalize the enzyme activities; the values were high for ethanolic extract treated group. The extracts were effective in a dose dependent manner with highest activity at 200 mg/kg body weight concentration. Similar results were obtained in case of lipid peroxidation.

Item Type: Article
Uncontrolled Keywords: Fasting diabetic rats; Total serum cholesterol; High density lipoprotein cholesterol ; Superoxide dismutase.
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 20 Jun 2014 10:12
Last Modified: 20 Jun 2014 10:12
URI: http://eprints.manipal.edu/id/eprint/139859

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