Investigation of wound healing activity of extracts from tinospora cordifolia

Rai, Padmalatha S (2011) Investigation of wound healing activity of extracts from tinospora cordifolia. Deccan Journal of Pharmacology, 2 (2). pp. 43-53. ISSN 0976-139X

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Abstract

Tinospora cordifolia is widely used in many parts of the world to manage a wide range of diseases. As part of efforts to elucidate its pharmacological activities and medicinal potential, we studied the wound healing properties of the extracts using experimentally created wounds in rodents. The present study was aimed for wound healing potential of ethanol, aqueous and pet ether extracts of Tinospora cordifolia (leaf, stem and root) using three types of wound models in rats such as incision wound, excision wound and dead space wound. The results were obtained in terms of wound contraction, epithelialization time, tensile strength, hydroxyproline content and granuloma weight. Enhanced wound contraction and decreased epithelialization time were observed in extract-treated animals in excision wound model. The tensile strength of the incision wound in extract treated animals was significantly increased in comparison to control group. The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in treated animals compared with control.

Item Type: Article
Uncontrolled Keywords: Excision; extracts; dead space; incision.
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 20 Jun 2014 10:41
Last Modified: 20 Jun 2014 10:41
URI: http://eprints.manipal.edu/id/eprint/139872

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