Clinico-Pathological correlation of the expression of Cyclin D1 And Bcl-2 in oral squamous cell carcinomas -A tissue microarray study

Solomon, Monica Charlotte and Vidyasagar, MS and Fernandes, Donald J and Guddattu, Vasudeva (2014) Clinico-Pathological correlation of the expression of Cyclin D1 And Bcl-2 in oral squamous cell carcinomas -A tissue microarray study. International Journal of Scienific Research, 3 (2). pp. 361-365. ISSN 2277 - 8179

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Abstract

Oral squamous cell carcinomas (OSCC)containa heterogenous tumor cell population that are at different stages of differentiation and with different levels of proliferative potential. Hence, the behavioural pattern of individual cases is poorly predictable. Several molecules play a vital role in the step-wise process of oral carcinogenesis. A better understanding of the interaction of these molecules will help in identifying the subgroup of patients with poor outcomes. Aim and Objective:To analyse the immunohistochemical expression of the cyclin D1 and bcl-2 in oral squamous cell carcinomas. To evaluate the possible association between cyclin D1 and Bcl-2 during the progression of oral squamous cell carcinomas. Settings and Design: A systematic approach of tissue microarray technology and immunohistochemistry analysis for a cohort of oral squamous cell carcinoma patients. Materials and methods: Formalin Fixed Paraffin Embedded (FFPE) tissue blocks of histological proven cases of OSCC (n=119) were selected. Tissue microarray (TMA)paraffin blocks were constructed using a “handy tissue microarrayer”. 4 μm thick sections were cut from the TMA blocks and the sections were immunostained with cyclin D1 and Bcl2. A semiquantitative analysis of the immunohistochemical expression of these markers in the tumor cells was carried out.

Item Type: Article
Uncontrolled Keywords: Oral Squamous cell carcinoma; tissue microarray; tumor grade; protein expression; prognosis.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Departments at MU > Statistics
Medicine > KMC Manipal > Radiotherapy and Oncology
Depositing User: KMC Manipal
Date Deposited: 21 Jun 2014 07:36
Last Modified: 21 Jun 2014 07:36
URI: http://eprints.manipal.edu/id/eprint/139895

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