Multiplication magnitude: Significance of epithelial cell proliferation in oral squamous cell carcinoma: A systematic review

Rakheja, Mahima and Grover, Jasleen and Chandrashekar, Chetana and Solomon, Monica C (2014) Multiplication magnitude: Significance of epithelial cell proliferation in oral squamous cell carcinoma: A systematic review. Research and Reviews: Journal of Dental Sciences, 2 (Supl-1). pp. 47-58. ISSN 2320-7949

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Abstract

To conduct a systematic review of literature to determine the role of proliferation of epithelial cells in the process of carcinogenesis of Oral Squamous Cell Carcinoma (OSCC) and highlight the several molecular markers which may be used to evaluate proliferative activity of cells. PUBMED, SCIENCE DIRECT, INTECH were used to search for English-language articles published from 1989 - 2013. Inclusion criteria consisted of population based studies of patients diagnosed with OSCC. 45 articles were thoroughly analysed to comprehend the concept of proliferative phase of cell cycle and the significance of the various associated molecular markers. Among them 27 were studies conduced on the markers of interest and remaining 18 were reviews. The studies have been taken from the year 1989 onwads, till 2013 and majority of the studies are from 2010 to 2013. Oral carcinogenesis is strongly determined by genetic factors determining epithelial cell proliferation. It is imperative to recognise and understand these factors as they can guide the selection of patients requiring more aggressive therapy and influence the prognosis.

Item Type: Article
Uncontrolled Keywords: Oral squamous cell carcinoma; cell proliferation; cell cycle; biomarkers; prognosis.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Manipal
Date Deposited: 21 Jun 2014 07:44
Last Modified: 21 Jun 2014 07:44
URI: http://eprints.manipal.edu/id/eprint/139900

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