Effectiveness of continuous pralidoxime (pam) infusion compared with repeated bolus injection in organophosphorus (op) poisoning

Raghavan, Padmaja and Amar, R and Nayak, Vinod C and Bakkannavar, Shankar M and Nayak, S and Ramachandran, V (2014) Effectiveness of continuous pralidoxime (pam) infusion compared with repeated bolus injection in organophosphorus (op) poisoning. International Journal of Biology, Pharmacy and Allied Sciences, 3 (5). pp. 761-775. ISSN 2277–4998

[img] PDF
EFFECTIVENESS OF CONTINUOUS PRALIDOXIME (PAM) INFUSION.pdf - Published Version
Restricted to Registered users only

Download (398kB) | Request a copy

Abstract

The poisoning due to pesticides is a worldwide problem. More so in the areas of developing countries due to easy availability of these compounds for agriculture, which most of the people in these countries depend upon for their livelihood. The patients with the history of pesticide consumption are treated effectively in the hospitals after diagnosis by the use of muscarinic antagonists (atropine) and the oximes (pralidoxime). Pralidoxime is often used with atropine to help reduce the parasympathetic effects of organophosphate poisoning. The use ofoxime is debatable due to its unclear fact about its effectiveness that the compound prevents mortality and morbidity. Even the route of its administration and the dosage are contentious while treating such patients. In the present study, the effectiveness of continuous Pralidoxime (PAM) infusion was compared with repeated bolus injection in Organophosphorus (OP) poisoning. It was found that the continuous infusion of PAM has better clinical improvement and less mortality.

Item Type: Article
Uncontrolled Keywords: Pesticides; atropine; oximes; bolus injection; continuous infusion.
Subjects: Medicine > KMC Manipal > Forensic Medicine
Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Manipal
Date Deposited: 23 Jun 2014 09:27
Last Modified: 23 Jun 2014 09:27
URI: http://eprints.manipal.edu/id/eprint/139902

Actions (login required)

View Item View Item