Correlation between spot urine protein creatinine ratio to 24-hour proteinuria in assessing diabetic nephropathy in type 2 diabetes mellitus

Boloor, Archith and Mutneja, Ashima and Rao, Jagadish Padubidri (2014) Correlation between spot urine protein creatinine ratio to 24-hour proteinuria in assessing diabetic nephropathy in type 2 diabetes mellitus. Journal of Pharmaceutical and Biomedical Sciences, 04 (07). pp. 633-637. ISSN 2230 – 7885

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Abstract

Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Persistent albuminuria is the hallmark of diabetic nephropathy (>300 mg/24 hr or 200 mcg/min), with additional criteria of the presence of diabetic retinopathy. Early screening for nephropathy in diabetes, with measurement of urinary albumin excretion is a very useful tool in the prevention of progression to chronic kidney disease. The wide spread use of 24hour urine protein excretion measurement forced the researchers to find a simpler and quicker method to get the result. One of the simpler methods is the use of spot single voided urine protein/creatinine ratio as an alternative to 24 hours urine collection. The aim of this study was to observe whether proteinuria measured, derived from a first morning void urine sample is same as a 24hour urinary albumin excretion (UAE) to diagnose micro albuminuria, and to know the PROTEIN: CREATININE RATIO in a first morning void urine sample and 24hour surine albumin excretion in type 2 diabetic patients. A total of 67 patients tested positive for micro albuminuria were included in the study after obtaining the informed consent for the same. From all these patients, two samples of urine were collected. (1) 24hour urine sample and (2) A first morning midstream urine sample.The utility of the spot morning urine as compared to the gold standard 24-hour proteinurea was inferred from: specificity, sensitivity, positive predictive value and negative predictive value. Correlation coefficient was computed to know the utility of the spot morning test and the 24hour proteinurea test. Regression analysis was calculated to predict the 24hour proteinurea. Our observations concluded that the first morning void albumin creatinine ratio is as good as the 24 hour urine albumin excretion in diagnosing micro albuminuria in type 2 diabetes mellitus.

Item Type: Article
Uncontrolled Keywords: Diabetic nephropathy; Type 2 Diabetes Mellitus; microalbuminuria; albumin creatinine ratio
Subjects: Medicine > KMC Mangalore > Forensic Medicine
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 08 Jul 2014 05:10
Last Modified: 08 Jul 2014 05:10
URI: http://eprints.manipal.edu/id/eprint/140043

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