Effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats

Shetty, Manjunath and Parida, Amrita and Adiga, Shalini and Kamath, Shobha and Sowjanya, * (2014) Effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats. Pharmacognosy Research, 6 (3). pp. 246-250. ISSN 0976-4836

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Abstract

Background: The effects and benefits of Acacia auriculiformis on health are not well established. This study was planned to evaluate the effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats. Materials and Methods: Learning and memory were evaluated using passive avoidance paradigm and rewarded alternation test (T‑maze) after the oral administration of two doses (200mg/kg and 400mg/kg) of ethanolic extract of Acacia auriculiformis with rivastigmine as positive control. Forty eight rats were divided into 4 groups in each study model. Estimation of brain cholinesterase activity was done to substantiate the results of the above mentioned tests. Data was analyzed using one way Analysis of Variance (ANOVA) followed by Tukey’s post‑hoc test using GraphPad InStat software, version 3.06. Results: The extract produced a dose‑dependent improvement in the memory score namely the step through latency in passive avoidance model (P < 0.001) and the percentage of correct responses in rewarded alternation test (P < 0.05). Dose‑dependent inhibition of brain cholinesterase activity (P < 0.001) was also noted. Conclusion: The acetylcholinesterase inhibiting property of Acacia auriculiformis contributes to its memory enhancing potential. Further large scale studies are required to elucidate its benefits on cognitive function. This may offer a promising new option for the treatment of dementia and other cognitive deficits.

Item Type: Article
Uncontrolled Keywords: Acacia auriculiformis; acetylcholinesterase; memory; passive avoidance; rewarded alternation.
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 09 Jul 2014 04:34
Last Modified: 09 Jul 2014 04:34
URI: http://eprints.manipal.edu/id/eprint/140049

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