Oral Cytology for HIV: A New Diagnostic Tool?

Jagad, Vaibhav Mahesh and Shenoy, Nandita and *, John Ramapuram and Lewis, Amitha and *, Srikant N and Sarin, Aditi (2014) Oral Cytology for HIV: A New Diagnostic Tool? Journal of the International Association of Providers of AIDS Care. pp. 1-4.

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Aim: To asses morphological and morphometrical alterations of oral squamous epithelial cells in HIV infected individuals, and determine its diagnostic significance for HIV infection. Materials and Methods: Informed Consent was obtained from all study subjects. 40 adult HIV infected patients (experimental group) and 40 adult non-infected volunteers (control group) participated. Age, occupation, and relevant medical history were recorded. The following laboratory tests reports were recorded: complete blood cell counts, blood glucose levels, serum iron and erythrocyte sedimentation rate. Oral smears were collected from normal appearing tongue and buccal mucosa of the individuals by exfoliative cytology. The cells were morphologically analysed and the nuclear area (NA), the cytoplasmic area (CA) and the nucleus-to-cytoplasm area ratio (NA/ CA) were calculated. Cell yield, cell cohesion, presence/absence of inflammatory cells and candida were observed. Results: The cytological smears of HIV patients showed abundant cell yield and the epithelial cells were found to be in close cohesive clusters and both findings were found to be statistically significant. Nuclear cytoplasmic ratio was seen to be increased in 93.8% of HIV positive patientsand Mild to moderate pleomorphism was observed in 17.9% of HIV positive patients. HIV positive patients had a diminished inflammatory response and this was found to be statistically significant. Conclusion: Statistically significant deviations from normal oral epithelium were found in the study conducted. With further research, oral exfoliative cytology may form a new, painless, inexpensive diagnostic method for HIV infections.

Item Type: Article
Uncontrolled Keywords: oral cytology, HIV, retro-positive, buccal smear, nucleocytoplasmic ratio
Subjects: Dentistry > MCODS Mangalore > Oral Medicine and Radiology
Depositing User: KMCMLR User
Date Deposited: 18 Jul 2014 07:04
Last Modified: 18 Jul 2014 07:04
URI: http://eprints.manipal.edu/id/eprint/140163

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