High Sensitivity Troponin T as a Marker of Silent Myocardial Injury in Diabetics

Datta, Priyanka and Rao, Pragna (2014) High Sensitivity Troponin T as a Marker of Silent Myocardial Injury in Diabetics. European Journal of Cardiovascular Medicine, 3 (1). pp. 312-316. ISSN 2042-4884

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Introduction: The new high sensitivity (hs) troponin T is specific biomarkers of myocardial necrosis.It has significant benefits for early recognition of acute myocardial infarction. CK-MB in serum is an important marker in diagnosis of myocardial ischemia.Aim and objective: We aimed to analyse and compare the relationship between glycated haemoglobin levels and hs troponin T, CK-MB in chronic hyperglycaemic patients as a marker of silent micro infarcts.Method and materials: hs Troponin T and CK-MB levels were measured using ECLIA and glycated haemoglobin by using HPLC method by variant turbo II.We grouped 119 chronic diabetic aged 30 - 70yrs in three categories according to HbA1c level Group A <6.5%, group B 6.5 – 8% and group C>8 %. Diabetic patients with cardiovascular disorder, renal failure, sepsis, skeletal muscle disorder and acute cholecystitis were excluded.Results: There was a 4 fold increase in values of hsTrop T in group II while 9.4 fold for group III in comparison to group I. CK-MB was elevated by 2.7 fold in group II and 3.11 in group III in comparison to group I.Conclusion:The prevalence of detectable hs-cTnT was increased in diabetic population and found specific than CK-MB to diagnose minimal myocardial cell injury. Troponin T levels can be used to detect early and minimal myocardial cell injury even in the presence of normal CK-MB. These data raise the possibility that hs Troponin T can be used as a predictor of minimal cardiac injury and micro infract in diabetic patients before symptoms manifest.

Item Type: Article
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 23 Jul 2014 04:26
Last Modified: 23 Jul 2014 04:26
URI: http://eprints.manipal.edu/id/eprint/140214

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