Grape seed extract and Zinc containing multivitamin-mineral nutritional food supplement ameliorates hepatic injury

Satyam, Shakta Mani and Bairy, KL and Rao, Mohandas KG and Nath, Mithun (2014) Grape seed extract and Zinc containing multivitamin-mineral nutritional food supplement ameliorates hepatic injury. Jokull Journal, 64 (6). pp. 184-195. ISSN 0449-0576

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Abstract

Background: Non-alcoholic fatty liver disease is principally a disease of middle and old age. In previous studies, we have reported combined formulation of grape seed extract and Zincovit tablets for its strong in vitro, in vivo antioxidant, anti-hyperglycemic and anti-cataractogenic potential. Objective: The present study was undertaken to investigate the hepatoprotective effect of single combined formulation of grape seed extract and Zincovit tablets (nutritional food supplement) against carbon tetrachloride-induced hepatic injury in Wistar rats. Methods: Hepatoprotective activity of combined formulation of grape seed extract and Zincovit tablets doses ranged from 40 to 160 mg/kg was evaluated in carbon tetrachloride induced hepatotoxic rats. Results: Oral administration of combined formulation of grape seed extract and Zincovit tablets for 7 days resulted in a significant reduction in serum alanine transaminase, aspartate transaminase, total bilirubin and direct (conjugated) bilirubin levels when compared with CCl4 intoxicated control rats (p <0.001). Profound fatty degeneration, fibrosis, and necrosis observed in the hepatic architecture of CCl4 intoxicated control animals were found to acquire near-normalcy in the animals treated with combined formulation of grape seed extract and Zincovit tablets. Conclusions: Our study opens the perspective to clinical studies which could improve the clinical outcome of elderly patients prone to hepatic impairment either due to age or other concomitant drugs therapy, a novel view likely to give rise to the performance of clinical trials devised to demonstrate the validity of this paradigm as nutritional food supplement.

Item Type: Article
Uncontrolled Keywords: Hepatic impairment; Age-related; Alanine transaminase ; Zincovit tablets ; Carbon tetrachloride ; Antioxidant.
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > MMMC Manipal > Anatomy
Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 30 Jul 2014 07:48
Last Modified: 30 Jul 2014 07:48
URI: http://eprints.manipal.edu/id/eprint/140277

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