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Factors Correlating with Severity of Coronary Artery Disease in Type 2 Diabetic Patients on Treatment for More Than 5 Years

*, Mukund P. Srinivasan and Kamath, Padmanabh K and Pai , Narasimha D and Manjrekar, Poornima and *, Chakrapani M (2014) Factors Correlating with Severity of Coronary Artery Disease in Type 2 Diabetic Patients on Treatment for More Than 5 Years. British Journal of Medicine & Medical Research, 4 (26). pp. 4364-4372.

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Abstract

Aims: To evaluate the correlation between insulin resistance and other conventional risk factors with respect to severity of coronary artery disease (CAD) in patients with more than 5 years of treatment for type 2 diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Department of Medicine and Department of Cardiology, Kasturba Medical College, Hospital Mangalore, between February 2013 and December 2013. Methodology: 61 people with more than 5 years of type 2 diabetes who underwent coronary angiogram for the evaluation of CAD were recruited in this study. Insulin resistance (HOMA-IR), anthropometric and biochemical parameters were determined, and was correlated with severity of CAD which was assessed by syntax score. Results: There was significant positive linear correlation between log HOMA-IR and syntax score in people with more than 5 years of type 2 diabetes [r=0.605 (95%CI 0.417–0.744), P<0.001]. The correlation of syntax score with other known risk factors of CAD was not significant. Further multivariate analysis after adjusting for conventional risk factors showed a significant association of Log-IR with severity of CAD in people with type 2 diabetes mellitus of more than 5 years of duration (β=0.667, P<0.001) Conclusion: In type 2 diabetes mellitus with treatment more than 5 years of duration, high HOMA-IR appears to be a good indicator of severity of CAD in Type 2 diabetes mellitus and might be a marker of severity of disease, thus helping us in identifying high risk type 2 diabetes mellitus subjects.

Item Type: Article
Uncontrolled Keywords: Insulin Resistance; type 2 diabetes mellitus; coronary artery disease; syntax score
Subjects: Medicine > KMC Mangalore > Biochemistry
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 01 Aug 2014 10:31
Last Modified: 01 Aug 2014 10:31
URI: http://eprints.manipal.edu/id/eprint/140307

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