Diabetes with Complication- scope of Serum Ceruloplasmin as a Biomarker

Prabhu, Krishnananda and Sharma, Devesh and Shenoy, Vijetha Belle and Gyawali, Prabin and Thakur, Rajesh Kumar (2014) Diabetes with Complication- scope of Serum Ceruloplasmin as a Biomarker. Journal of International Academic Research For Multidisciplinary, 2 (5). pp. 841-846.

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Diabetes mellitus, a chronic non communicable disease is one of the most common burden in India. Complications associated with diabetes are coronary artery disease, nephropathy and neuropathy. Angiogenesis and coagulation are involved in the pathogenesis of diabetic complications. Ceruloplasmin, a ferroxidase enzyme in human encoded by Ceruloplasmin gene. The one of the main function of ceruloplasmin is its involvement in angiogenesis and coagulation. The use of serum ceruloplasmin as a marker of diabetic complication is less known. The objective of the study was to understand the usefulness of serum ceruloplasmin in individuals with diabetes as well as individuals with complications of diabetes. Ethical clearance was obtained from institutional ethical committee prior to the blood collection. Totally 163 individuals of 40-60 years of age were included in the study. Serum ceruloplasmin levels were measured by O-Dianisidine Method. Statistical analysis was done using SPSS 16.0 version. P value > 0.05 is said t o be significant. Serum ceruloplasmin levels were lesser in those who did not have the complications of diabetes. There is no statistically significant difference in the serum ceruloplasmin levels in individuals with diabetes and those with complications of diabetes. Loss of glomerular charge selectivity and impairment of glomerular pore size selectivity may be the reason for increased excretion of urinary ceruloplasmin and decreased serum ceruloplasmin levels. Studies with large number of subjects might give better results and may through light on the pathogenesis of complications of diabetes.

Item Type: Article
Uncontrolled Keywords: Diabetes Mellitus; Ceruloplasmin; Nephropathy
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 06 Aug 2014 09:25
Last Modified: 17 Oct 2014 06:33
URI: http://eprints.manipal.edu/id/eprint/140342

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