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Scavenging role of BETA carotene in oxidative stress induced by cadmium chloride on rat testis

Kini, Rekha D and *, Nayanatara AK and *, Anupama N and *, Bhagyalakshmi K and Pai, Sheila R and Shetty, Sneha B (2014) Scavenging role of BETA carotene in oxidative stress induced by cadmium chloride on rat testis. International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 1 (4). pp. 89-92. ISSN 2348-5213

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Abstract

Cadmium is a transitional metal that exists in different oxidational or transitional states in the environment. It is a wellknown caricinogen and a potent testicular toxicant. Cadmium is known to affect various organs like kidney, liver, bone and testis in human beings and experimental animals. The present study was aimed to study the anti-oxidative role of beta carotene against cadmium chloride induced oxidative stress on rat testis. Adult male rats(n=8/group) were divided into five groups, one control (Gr.I- 0.9% saline treated) & two untreated experimental & two pretreated experimental groups. The untreated groups were injected with single dose of 0.5 & 1 mg /kg body weight cadmium chloride (Gr.II &Gr.III) intraperitoneally. Beta carotene (10mg/kg body weight) was orally administered for 30 days prior to the exposure to 0.5and 1mg/kg body weight (Gr,IIa&Gr.IIIA) of cadmium chloride. In all the groups, rats were sacrificed15 days after the final cadmium chloride or saline administration and the changes in the testicular weight and testicular level of Malonaldehyde , glutathione & superoxide dismutase were studied. Exposure to cadmium chloride lead to significant decrease in the testicular weight & level of GSH & SOD and increase in the level of testicular MDA compared to normal control. Beta carotene pretreatment significantly prevented the increase in MDA level of the testis & ameliorated the fall in GSH & SOD as well as testicular weight when compared to 0.5mg/kg body weight cadmium chloride group. But pretreatment with beta carotene did not show any beneficial effect with 1mg/kg body weight cadmium treated group. Thus the results of the present study showed that the antioxidative role of beta carotene in ameliorating lower doses of cadmium.

Item Type: Article
Uncontrolled Keywords: Cadmium, Glutathione, Beta Carotene, lipid peroxidation
Subjects: Medicine > KMC Mangalore > Physiology
Depositing User: KMCMLR User
Date Deposited: 07 Aug 2014 07:10
Last Modified: 07 Aug 2014 07:10
URI: http://eprints.manipal.edu/id/eprint/140351

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