Alcoholism and Its Role in the Development of Oxidative Stress and DNA Damage: An Insight

Rao, Pragna (2014) Alcoholism and Its Role in the Development of Oxidative Stress and DNA Damage: An Insight. American Journal of Medical Sciences and Medicine, 2 (3). pp. 64-66.

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Abstract

Alcohol is detoxified in the liver by the enzymes alcohol dehydrogenase and aldehyde dehydrogenase. The available literature suggests that activity of aldehyde dehydrogenase is less than alcohol dehydrogenase among Asians; hence it leads to accumulation of acetaldehyde during excess intake of alcohol. Accumulated acetaldehyde due to its electrophilic nature forms adducts with proteins and DNA. The acetaldehyde-DNA adduct (N-2-Ethyl deoxyguanosine (NDG)) induces mutations in DNA and leads to DNA damage. Prevention of excessive accumulation of acetaldehyde can be useful in decreasing the genotoxicity

Item Type: Article
Uncontrolled Keywords: Alcoholism; Alcohol dehydrogenase; Aldehyde dehydrogenase; N-2-Ethyl deoxyguanosine (NDG); Oxidative stress
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 09 Aug 2014 07:40
Last Modified: 09 Aug 2014 07:40
URI: http://eprints.manipal.edu/id/eprint/140355

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