Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers

Honnegowda, Thittamaranahalli Muguregowda and Kumar, Pramod and Udupa, Padmanabha and Rao, Pragna and Bhandary, Siddhartha and Mahato, Krishna Kumar and Sharan, Anurag and Mayya, Shreemathi S (2014) Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers. Indian Journal of Plastic Surgery , 47 (2). pp. 216-220.

[img] PDF
ijps_2014_47_2_216_138952.pdf - Published Version
Restricted to Registered users only

Download (12MB) | Request a copy

Abstract

Background: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. Materials and Method: A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17). Results: Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045). Conclusion: Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.

Item Type: Article
Uncontrolled Keywords: Chronic ulcers; chronic wound-healing; enzymatic antioxidants; hydroxyproline; limited access dressing; total protein.
Subjects: Medicine > KMC Manipal > Biochemistry
Departments at MU > Statistics
Medicine > KMC Manipal > Plastic Surgery
Medicine > KMC Manipal > Surgery
Depositing User: KMC Manipal
Date Deposited: 18 Aug 2014 07:35
Last Modified: 18 Aug 2014 07:35
URI: http://eprints.manipal.edu/id/eprint/140384

Actions (login required)

View Item View Item