Role of Statins in Periodontitis- An overview

Shetty, Shilpa and Shetty, Mranali K (2014) Role of Statins in Periodontitis- An overview. International Journal of Advanced Research, 2 (8). pp. 763-765. ISSN 2320-5407

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Abstract

Periodontal disease is a chronic inflammatory disease which represents a primarily anaerobic Gram-negative oral infection that results in gingival inflammation, loss of attachment, bone destruction. Certain organisms within the microbial flora of dental plaque are the major etiologic agents of periodontitis which produce endotoxins in the form of lipopolysaccharides (LPS) that are instrumental in generating a host‑mediated tissue destructive immune response by mobilizing their defensive cells and releasing cytokines like Interleukin‑Tumor Necrosis Factor, and Interleukin‑6 (IL‑6),which lead to tissue destruction by stimulating the production of the collagenolytic enzymes: Matrix metalloproteinases (MMPs). Statins, 3-hydroxy-3-methylglutarylcoenzyme A (HMG CoA) reductase inhibitors, besides having lipid-lowering abilities also have antioxidant, antithrombotic, anti-inflammatory, immunomodulatory and osteomodulatory properties. All of these pleiotropic effects of statins point out to it perhaps becoming the novel host modulation agent in periodontics.

Item Type: Article
Subjects: Dentistry > MCODS Mangalore > Periodontics
Depositing User: KMCMLR User
Date Deposited: 10 Sep 2014 06:51
Last Modified: 10 Sep 2014 06:51
URI: http://eprints.manipal.edu/id/eprint/140600

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