Antibiotic utilization in patients with complicated urinary tract infection in the medicine wards of a South Indian tertiary care teaching hospital

Faryabi, Rouhollah and Mathew, Joice and Palaye, Mrunmayee and Nair, Sreedharan and Shivshankar, * and Shetty, Prasanna Kumar and Thunga, Girish and Kunhikatta, Vijayanarayana (2014) Antibiotic utilization in patients with complicated urinary tract infection in the medicine wards of a South Indian tertiary care teaching hospital. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5 (4). pp. 87-93. ISSN 0975-8585

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Abstract

Complicated urinary tract infection (cUTI) is a major issue in the present day because of the wide variety of antibiotics required for its treatment. This study aimed to identify the organisms isolated, sensitivity pattern and utilization of antibiotics in cUTI and the outcome of the therapy. A retrospective cohort study was conducted using medical records of 297 patients diagnosed with cUTI. Patient demography, organisms isolated and their sensitivity pattern, antibiotic regimen used and outcome were recorded and assessed using SPSS 18. The most isolated organisms responsible for cUTI were ESBL Ecoli which was found to be very sensitive to cefoperazone-sulbactum, amikacin and to carbapenems and Ecoli which was found to be sensitive to most antibiotics. Dual drug regimen was the most preferred treatment. Among the different category of antibiotics used, cephalosporins were the most commonly prescribed. The use of dual drug regimen for the treatment of cUTI was found to produce more significant outcomes than the other regimens. The organisms isolated were found to be most sensitive to cephalosporins, amikacin and carbapenems. Cephalosporins were the most effective antibiotics for the treatment of cUTI. The limitations of this study were small sample size and the unavailability of culture reports for many patients.

Item Type: Article
Uncontrolled Keywords: ESBL Ecoli; urinary infections; cephalosporins; sensitivity pattern; risk factors.
Subjects: Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 27 Sep 2014 09:21
Last Modified: 27 Sep 2014 09:21
URI: http://eprints.manipal.edu/id/eprint/140744

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