An appraisal of sensitivity and resistance pattern of organisms isolated from hospital aquired pneumonia patients

Kunhikatta, Vijayanarayana and Rau, NR and Naik, Anantha Nagappa and Bhavani, Y and Thunga, Girish and Nair, Sreedharan (2014) An appraisal of sensitivity and resistance pattern of organisms isolated from hospital aquired pneumonia patients. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5 (4). pp. 384-398. ISSN 0975-8585

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Abstract

Hospital acquired pneumonia (HAP) is an infection of lung parenchyma develops at least after 48 hours of hospitalization for another illness or procedure, also known as nosocomial pneumonia. Organisms causing HAP were found in 221 (43.7%) out of 505 patients. The most common isolates found were Klebisiella pneumonia (30.9%) Acinetobacter species (29.4%), Pseudomonas aeruginosa (16.7%), Escherichia coli (9.1%) and methicillin resistant Staphylococcus aureus (MRSA; 3.7%, 73%). Sensitivity pattern of gram negative organisms such as Klebisiella pneumonia, Acinetobacter species and Escherichia coli was comparatively identical showing high sensitivity towards colistin and tigecycline where as Pseudomonas aeruginosa was highly sensitive to only colistin. Among Ggram positive organisms MRSA was highly sensitive to linezolid, tetracycline and cotrimoxazole, methicillin sensitive Staphylococcus aureus to (MSSA) cotrimoxazole (80%) and tetracycline (71.4%) and Streptococcus pneumonia to chloramphenicol, penicillin, piperacillin, cefoperazone-sulbactam and colistin. Sensitivity pattern of Gram negative organisms was different from that of Gram positive organisms causing high mortality rates. Among Gram positive organisms MRSA caused mortality as twice as that of MSSA. Multidrug resistant strains were resulted by inappropriate and inadequate antibiotic therapy, causing high rate of morbidity mortality and adding cost to therapy which is the major concern in recent times.

Item Type: Article
Uncontrolled Keywords: Hospital acquired pneumonia; klebisiella pneumonia; antibiotic; mortality and multidrug resistant strains.
Subjects: Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmacy Management
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 27 Sep 2014 09:25
Last Modified: 27 Sep 2014 09:25
URI: http://eprints.manipal.edu/id/eprint/140747

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