Solubility enhancement of norfloxacin by hydrotropy technique

Pai, Girish K and Divya, S and Reddy, Sreenivasa M and Kumar, Lalit and Krishna, Vamshi T (2014) Solubility enhancement of norfloxacin by hydrotropy technique. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (8). pp. 395-397. ISSN 0975-1491

[img] PDF
Vamshi Krishna.pdf - Published Version
Restricted to Registered users only

Download (247kB) | Request a copy

Abstract

The objective of this study is to improve the solubility of poorly water soluble anti-bacterial drug Norfloxacin by hydrotropic solubilization technique. For the present study sodium benzoate was used as hydrotropic agent. By using this hydrotropic agent as water soluble carrier, hydrotropic solid dispersions of Norfloxacin were prepared.in 1:1, 1:2, 1:3 and 1:4 ratios (drug: hydrotropic agent). Equilibrium solubilization of pure drug and hydrotropic solid dispersions of Norfloxacin in distilled water by excess solute method and solubility enhancement ratios were calculated by measuring the absorbance of the solutions at 274.80 nm using UV spectrophotometer. The hydrotropic agent did not interfere in analysis. The results showed that there was an increase in the solubility of Norfloxacin with hydrotropic solid dispersions compared to pure drug in distilled water. There was 9.56 fold enhancement in aqueous solubility of Norfloxacin with hydrotropic solid dispersion of 1:4 ratio compared to 1:1 (6.29), 1:2 (7.09) and 1:3 (8.59) ratios.

Item Type: Article
Uncontrolled Keywords: Hydrotropy; Solubility enhancement; Norfloxacin.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 29 Sep 2014 04:23
Last Modified: 29 Sep 2014 04:23
URI: http://eprints.manipal.edu/id/eprint/140754

Actions (login required)

View Item View Item