Beta Carotene as an Antioxidant in Cadmium Induced Testicular Toxicity

Kini, Rekha D and *, Nayanatara AK and *, Anupama N and *, Bhagyalakshmi K and Pai, Sheila R and Shetty, Sneha B (2014) Beta Carotene as an Antioxidant in Cadmium Induced Testicular Toxicity. International Journal of Current Research in Biosciences and Plant Biology, 1 (3). pp. 61-66. ISSN 2349-8080

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Abstract

Aim of present study was evaluate the anti-oxidative role of beta carotene against cadmium chloride induced oxidative stress on rat testis. Rats were divided into Group-I (0.9% Saline treated), Group-II (Beta carotene treated for 30 days), Group-III (injected with single dose of 1 mg/kg body weight cadmium chloride) and Group-IIIA (Beta carotene for 30 days+ cadmium administration). In all the groups, rats were sacrificed 15 days after the final cadmium chloride or saline administration. Exposure to cadmium chloride lead to significant (p<0.001) decrease in the epididymal weight and sperm count compared to Group-I and Group-II. Standard Tubular Diameter (STD) and Standard Epithelial Height (SEH) was also low in Group-III animals compared to Group-I and Group-II. Photomicrograph of rats in Group-I and Group-II showed normal architecture of testis and rats treated with cadmium chloride showed the destruction of the seminiferous tubules. But, rats of Group-IIIA showed significant (p<0.001) increase in epididymal weight and sperm count compared to Group-III. STD and SEH was also significantly (p<0.001) high in Group-IIIA. Photomicrograph of rat testis in Group-IIIA showed almost normal testicular architecture. Results of the present study showed the antioxidative role of beta carotene in ameliorating cadmium induced testicular damage.

Item Type: Article
Uncontrolled Keywords: Antioxidant Cadmium Beta carotene Sperm count Standard tubular diameter
Subjects: Medicine > KMC Mangalore > Physiology
Depositing User: KMCMLR User
Date Deposited: 07 Oct 2014 07:00
Last Modified: 07 Oct 2014 07:00
URI: http://eprints.manipal.edu/id/eprint/140784

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