Synthesis, Characterisation and useful Therapeutic Activity of Novel 2- Quinolone Derivatives

Jayashree, BS and Sharma, N and Nigam, S (2013) Synthesis, Characterisation and useful Therapeutic Activity of Novel 2- Quinolone Derivatives. Indian Drugs, 50 (12). pp. 41-46.

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A series of novel 2-oxo-1,2,3,4-tetrahydroquinolin-7-yl benzoate derivatives were synthesised andobtained in moderate yields (55-85%) by the reaction of parent 7-hydroxy-1,2,3,4-tetrahydroquinolin-2-one (7-hydroxy-3,4-dihydroquinolin-2(1H)-one) with substituted benzoyl chlorides. The synthesisedtest compounds were characterised by spectral analysis. Partition coefficient was determined for alltest compounds and was found to be in the range of 1.2-2.9. Further, the compounds were screenedfor their antibacterial and antioxidant activities. They were also randomly screened for their antidiabeticpotential by non-enzymatic glycosylation of haemoglobin assay. However, the results revealed that testcompounds did not possess antioxidant and antidiabetic potential comparable to that of their respectivestandards. The results also revealed that most of the compounds exhibited antibacterial action againstfour bacterial strains namely Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa andEscherichia coli. Further, the test compound VIIl (at 500 ?g mL-1), showed zone of inhibition comparableto that of the standard ciprofloxacin (at 500 ?g mL-1).

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 08 Oct 2014 11:41
Last Modified: 08 Oct 2014 11:41

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