MU Digital Repository
Logo

Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: Mechanistic aspects and antioxidant activity

Kumar, Sudheer and Unnikrishnan, MK (2005) Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: Mechanistic aspects and antioxidant activity. Free Radical Research, 39 (11). pp. 1163-1172. ISSN 1071-5762

[img] PDF
2005 Free radical Res.pdf - Published Version
Restricted to Registered users only

Download (580kB) | Request a copy

Abstract

Reactions of sulfasalazine (SAZ) and its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), with various oxidizing and reducing free radicals (hydroxyl, haloperoxyl, one-electron oxidizing, lipid peroxyl, glutathiyl, superoxide, tryptophanyl, etc.) have been studied to understand the mechanistic aspects of its action against free radicals produced during inflammation. Nanosecond pulse radiolysis technique coupled with transient spectrophotometry has been used for in situ generation of free radicals and to follow their reaction pathways. The transients produced in these reactions have been assigned and radical scavenging rate constants have been measured. In addition to scavenging of various primary and secondary free radicals by SAZ, 5-ASA and SP, 5-ASA has also been observed to efficiently scavenge radicals of biomolecules. 5-ASA has been found to be the active moiety of SAZ involved in the scavenging of oxidizing free radicals whereas reduction of SAZ produced molecular radical anion. The study suggests that free radical scavenging activity of 5-ASA may be a major path of pharmacological action of SAZ against inflammatory bowel diseases (IBD).

Item Type: Article
Uncontrolled Keywords: Sulfasalazine; 5-aminosalicylic acid; pulse radiolysis; free radicals; antioxidant; kinetics and mechanism.
Subjects: Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 20 Oct 2014 04:07
Last Modified: 20 Oct 2014 04:07
URI: http://eprints.manipal.edu/id/eprint/140891

Actions (login required)

View Item View Item