Benzopyran-4-one is an ideal pharmacophore for lead optimization in antidiabetic drug discovery

Nayak, Yogendra and Jayashree, BS and Unnikrishnan, MK (2012) Benzopyran-4-one is an ideal pharmacophore for lead optimization in antidiabetic drug discovery. Research Journal of Pharmacy and Technology, 5 (8). pp. 1025-1033. ISSN 0974-3618

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Abstract

Diabetes mellitus (DM) is a metabolic disorder associated with retinopathy, nephropathy, cardiomyopathy, peripheral neuropathy and autonomic neuropathies leading to gastrointestinal, genitourinary, cardiovascular complications and sexual dysfunction. The present available antidiabetic agents are not interferingin the modulation of these complications. Benzopyran-4-one is the basic moiety present in naturally occurring flavonoids. Number of flavonoids hasbeen found to be antidiabetic and many of themmodulate diabetes related complications by acting on newer targets. Hence, an attempt was made to review the possibilities of modulating benzopyran-4-one scaffold for lead optimizationin antidiabetic drug discovery.

Item Type: Article
Uncontrolled Keywords: Diabetes mellitus; benzopyran-4-one; flavonoids; antidiabetic; lead optimization.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 20 Oct 2014 04:15
Last Modified: 20 Oct 2014 04:15
URI: http://eprints.manipal.edu/id/eprint/140894

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