Antihyperglycemic and antioxidant potential of polysaccharide fraction from portulaca oleracea seeds against streptozotocin-induced diabetes in rats

Unnikrishnan, MK (2012) Antihyperglycemic and antioxidant potential of polysaccharide fraction from portulaca oleracea seeds against streptozotocin-induced diabetes in rats. Journal of Food Biochemistry, 36. pp. 378-382. ISSN 1745-4514

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Abstract

The present study envisaged the antidiabetic and antioxidant potential role of polysaccharide fraction of Portulaca oleracea (P. oleracea polysaccharide fraction [PPFt]) against streptozotocin (STZ)-induced (50 mg/kg, intraperitoneal) diabetes in experimental animals. After 3 weeks of oral treatment with PPFt (25 and 50 mg/ kg), significant dose-dependent reduction in blood glucose, Thiobarbituric Acid Reactive Substances and subsequent increase in total reduced glutathione levels and glutathione peroxidase activity was observed in the diabetic animals. Enzymatic antioxidant defense, catalase and superoxide dismutase were significantly reduced after STZ administration and concomitant administration of PPFt significantly reversed the levels of these enzymes near to normal values. These findings strongly indicate that PPFt could protect against the STZ-induced hyperglycemia and disturbance in lysosomal enzymes in a dose-dependent manner.

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 20 Oct 2014 04:31
Last Modified: 20 Oct 2014 04:31
URI: http://eprints.manipal.edu/id/eprint/140899

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