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Clinico‑pathological correlation of E‑cadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: An immunohistochemical study

*, Monica Mehendiratta and Solomon, Monica Charlotte and Boaz, Karen and Guddattu, Vasudeva and *, Aashima Mohindra (2014) Clinico‑pathological correlation of E‑cadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: An immunohistochemical study. Journal of Oral and Maxillofacial Pathology, 18 (2). pp. 217-222. ISSN 0973-029X

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Abstract

Background: Recent studies have indicated that although malignant cells at the invasive tumor front, bare morphological resemblance to the cells at central portion of the tumor, their molecular character differs significantly. E‑cadherin is a cell‑cell adhesion molecule that connects epithelial cells. This study attempts to correlate the E‑cadherin expression at the invasive tumor front with tumor differentiation along with its clinico‑pathological parameters. Materials and Methods: Immunohistochemical staining with E‑cadherin was carried out on archival cases of primary oral squamous cell carcinomas (n = 30). The E‑cadherin expression at the invasive tumor front was analyzed and was linked to clinico‑pathological parameters including patient prognosis. Results: The downregulation of E‑cadherin expression at the invasive tumor edge when compared with patient’s prognosis yielded a significant correlation (P = 0.041) but its correlation with the degree of differentiation determined was not significant (P = 0.27). Also, its association with tumor size and lymph node status was negative. Conclusions: Loss of E‑cadherin expression at the invasive tumor front is an important event in the progression of oral squamous cell carcinomas. Tumors with a loss of expression of E‑cadherin are those which had a poor prognosis

Item Type: Article
Uncontrolled Keywords: Differentiation, E‑cadherin, invasive tumor front, oral cancer, prognosis
Subjects: Dentistry > MCODS Mangalore > Oral Pathology
Depositing User: KMCMLR User
Date Deposited: 29 Oct 2014 11:16
Last Modified: 29 Oct 2014 11:16
URI: http://eprints.manipal.edu/id/eprint/140934

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