Preparation and characterization of novel PBAE/PLGA polymer blend microparticles for DNA vaccine delivery

Balashanmugam, Meenashi Vanathi and Nagarethinam, Sivagurunathan and Jagani, Hitesh and Rao, Venkata Josyula and Udupa, N (2014) Preparation and characterization of novel PBAE/PLGA polymer blend microparticles for DNA vaccine delivery. The Scientific World Journal, 2014. pp. 1-9.

[img] PDF
Dr N Udupa.pdf - Published Version
Restricted to Registered users only

Download (1MB) | Request a copy

Abstract

Context. Poly(beta-amino ester) (PBAE) with its pH sensitiveness and Poly(lactic-co-glycolic acid) (PLGA) with huge DNA cargo capacity in combination prove to be highly efficient as DNA delivery system. Objective. To study the effectiveness of novel synthesized PBAE polymer with PLGA blend at different ratios in DNA vaccine delivery. Methods. In the present study, multifunctional polymer blend microparticles using a combination of PLGA and novel PBAE polymers A1 (bis(3-(propionyloxy) propyl)3,3

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Depositing User: KMC Manipal
Date Deposited: 03 Nov 2014 04:29
Last Modified: 03 Nov 2014 04:29
URI: http://eprints.manipal.edu/id/eprint/140959

Actions (login required)

View Item View Item