Patel, Alkesh and Biswas, Subhankar and Shoja, Muhammed Haneefa and Ramalingayya, Grandhi Venkata and Nandakumar, K (2014) Protective effects of aqueous extract of solanum nigrum linn. leaves in models of oral mucositis. The Scientific World Journal, 2014. pp. 1-10.

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Abstract

Oralmucositis is one of themost debilitating side effects in patient undergoing chemotherapy or chemoradiotherapy. Leaves of the plant Solanum nigrum are used in folklore medicine to treat oral ulcers in India. However, no pharmacological investigation has been carried out till date. Aqueous extract of Solanum nigrum leaves (AESN) was prepared and subjected to various phytochemical screening. HPLC analysis of the ethyl acetate fraction was carried out. The aqueous extract (100 and 200mg/kg) was further evaluated for its protective effect on two rat models: (a) busulfan plus infrared radiation (chemoradiotherapy) induced oral mucositis and (b) methotrexate (chemotherapy) induced oral mucositis. Various parameters including body weight change, food intake, and mortality were measured. AESN showed protective effect in both models of oral mucositis; however, the higher dose was more effective in chemotherapy induced oral mucositis. A reduction in oral mucositis score (

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