Design, synthesis, docking study & antibacterial evaluation of 1,3-Ddiarylpyrazolyl substituted Indolin-2-ones

Bansal, Sumit and Kumar, Sharad and Joseph, Alex (2014) Design, synthesis, docking study & antibacterial evaluation of 1,3-Ddiarylpyrazolyl substituted Indolin-2-ones. Indo Global Journal of Pharmaceutical Sciences, 4 (1). pp. 1-7. ISSN 2249-1023

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Abstract

In the present investigation, a series ofnovel 3-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)indolin-2-one was synthesized by the Claisen-Schmidt condensation of indolin-2-one with substituted diaryl formylpyrazoles using alcoholic sodium hydroxide. The chemical structures of the newly synthesized compounds were characterized by IR, 1HNMR, and mass spectroscopy. The title compounds were evaluated for qualitative (zone of inhibition) and quantitative antibacterial activity (MIC) by agar diffusion and broth microdilution MIC (minimum inhibitory concentration) methods, respectively against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae. All the synthesized compounds were found active against Gram-positive bacteria, while showed very weak activity against Gram-negative bacteria. Docking study was performed to check interaction of synthesized compounds with the target DNA gyrase.

Item Type: Article
Uncontrolled Keywords: Pyrazoles; Indolin-2-ones; antibacterial; docking; DNA gyrase.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 29 Nov 2014 09:22
Last Modified: 29 Nov 2014 09:22
URI: http://eprints.manipal.edu/id/eprint/141165

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