Influence of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement on lipid profile in normal and diet-induced hypercholesterolemic rats

Satyam, Shakta Mani and Bairy, KL (2014) Influence of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement on lipid profile in normal and diet-induced hypercholesterolemic rats. Journal of Clinical and Diagnostic Research, 8 (12). pp. 12-15. ISSN 0973-709X

[img] PDF
c Containing Multivitamin-Mineral Nutritional Food Supplement on Lipid Profile in Normal and Diet-Induced Hypercholesterolemic Rats.pdf - Published Version
Restricted to Registered users only

Download (871kB) | Request a copy

Abstract

Background: Zincovit tablet is combination of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement. Aims: To investigate the influence of single combined formulation of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement tablets (Zincovit) on lipid profile in normal and diet-induced hypercholesterolemic rats. Materials and Methods: Anti-hyperlipidemic activity of combined formulation of grape seed extract and Zincovit tablets doses ranged from 40 to 160 mg/kg, p.o. was evaluated in normal and diet-induced hypercholesterolemic rats. Results: Hypercholesterolemic animals treated with combined formulation of grape seed extract and Zincovit tablets (nutritional food supplement) at 40, 80 and 160 mg/kg exhibited drastic decrease in serum triglycerides, total cholesterol, LDL-C, VLDL-C and rise of HDL-C in comparison to hypercholesterolemic control group animals. The anti-hyperlipidemic effect of single combined formulation of grape seed extract and Zincovit tablet was comparable with the standard drug atorvastatin treated animals and the variations were statistically non-significant. There was no significant impact of combined formulation of grape seed extract and Zincovit tablets on lipid profile among normal animals in comparison with normal control group. Conclusion: The present study demonstrated that the single combined formulation of grape seed extract and Zincovit tablet is the potential functional nutritional food supplements that could offer a novel therapeutic opportunity against diet-induced hypercholesterolemia in Wistar rats.

Item Type: Article
Uncontrolled Keywords: Antioxidant; atherosclerosis; atorvastatin; grape seed extract; cardiovascular disease; reactive oxygen species; zincovit tablets.
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 26 Dec 2014 04:24
Last Modified: 26 Dec 2014 04:58
URI: http://eprints.manipal.edu/id/eprint/141363

Actions (login required)

View Item View Item