Effect of fucithalmic and sofinox eye drops on experimental allergic conjunctivitis in rats

Satyam, Shakta Mani and Adiga, Shalini and Chogtu, Bharti and Bairy, KL and Pirasanthan, Rajadurai and Vaishnav, Rajdip Lalit (2014) Effect of fucithalmic and sofinox eye drops on experimental allergic conjunctivitis in rats. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (11). pp. 458-460. ISSN 0975-1491

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Abstract

Objective: To investigate the therapeutic effect of Fucithalmic 1%, Sofinox 0.5% and 1% eye drops against an IgE-mediated allergic conjunctivitis model in Wistar rats. Methods: IgE-mediated allergic conjunctivitis was induced by ovalbumin antigen challenge. Allergic conjunctivitis induced control rats (Group I) received normal saline (0.9% NaCl; 10 μl/eye) whereas Fucithalmic 1% (Group II), Sofinox 0.5% (Group III) and 1% (Group IV) were administered as 10, 20 and 10 μl/eye respectively to the treatment group animals (n=6) for 15 days. Eye scratching behavior, hypothermia and edema was evaluated after topical antigen challenge. Results: Sofinox 1% eye drops (10 μl/eye) significantly attenuated eye scratching behavior, hyperemia and edema in comparison with allergic conjunctivitis induced control (p < 0.001) and Fucithalmic 1% treated rats (p < 0.05). Eye scratching behavior and edema was also significantly decreased in Sofinox 0.5% eye drops (20 μl/eye) treatment group as compared to allergic conjunctivitis induced control rats (p < 0.05). Conclusion: The present study revealed that the Sofinox eye drop is the potential agent that could offer a novel therapeutic opportunity against IgE-mediated allergic conjunctivitis in Wistar rats.

Item Type: Article
Uncontrolled Keywords: Allergic conjunctivitis; sofinox; fucithalmic; IgE.
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 26 Dec 2014 04:33
Last Modified: 26 Dec 2014 04:33
URI: http://eprints.manipal.edu/id/eprint/141366

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