Bernhardt, Liegelin Kavitha and Bairy, Lakshminarayana K. and Madhyastha, Sampath (2015) N-Acetylcysteine reverses late gestational stress induced maternal oxidative damage. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (1). pp. 165-168. ISSN 0975-1491

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Abstract

Objective: This study was intended to investigate the effect of early and late gestational stress, on the levels of antioxidants and antioxidant enzymes in maternal serum that reflects oxidative damage. We also aimed at evaluating the protective role of N-acetylcysteine (NAC) against this oxidative stress. This study was carried out with speculation in mind that maternal oxidative damage could be the cause for developmental defects in off spring. Methods: Pregnant rats were exposed to restrain stress thrice daily, either during the first half or during the second half of gestation. Other groups were treated with N-acetylcysteine throughout pregnancy, along with exposure to either early gestational stress or late gestational stress. Control group was kept undisturbed throughout pregnancy. Immediately after delivery, blood was drawn to estimate the serum antioxidant levels. Results: Pregnant rats exposed to stress during the late gestational period showed significant variation in the level of serum MDA, Glutathione Reductase, reduced glutathione, SOD and total antioxidant capacity although, administration of NAC brought about improvement in the antioxidant status. Conclusion: NAC is an effective antioxidant that can bring down the oxidative damage caused by late gestational stress in rats.

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