TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling

Sharma, Jyoti and Prasad, Keshava TS (2014) TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling. Database, 2014. pp. 1-8.

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Abstract

Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor a chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-anno ated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this importantm cytokine as well as to identify novel therapeutic ets for diseases associated with dysregulated TSLP/TSLPR signaling.

Item Type: Article
Subjects: Departments at MU > Sciences
Depositing User: KMC Manipal
Date Deposited: 09 Jan 2015 04:19
Last Modified: 09 Jan 2015 06:22
URI: http://eprints.manipal.edu/id/eprint/141498

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