MU Digital Repository
Logo

Discrimination of Normal Inflammator Premalignant and Malignant Oral Tissue: A Raman Spectroscopy Study

Malini, R and Venkatakrishna, K and Kurien, J and Pai, Keerthilatha M and Rao, Lakshmi and Kartha, VB and Murali Krishna, C (2006) Discrimination of Normal Inflammator Premalignant and Malignant Oral Tissue: A Raman Spectroscopy Study. Biopolymers, 81. 179- 193 .

[img] PDF
Discrimination_of_normal_inflammatory,_pre-malignant_and_malignant_oral_tissue_A_Raman_Spectrosco.pdf - Published Version
Restricted to Registered users only

Download (416kB) | Request a copy

Abstract

Optical spectroscopy methods are fast emerging as potential alternatives for early diagnosis of cancer. A Raman spectroscopy method for discrimination of normal and malignant oral tissues has been developed by us earlier. It is necessary to evaluate and establish the validity of the approach before it can be routinely used. In the present study, our Raman spectroscopy investigations are extended further to evaluate the efficacy of the technique to discriminate between normal, inflammatory, premalignant, and malignant conditions in oral tissue. Spectral profiles of normal, malignant, premalignant, and inflammatory conditions show pronounced differences between one another. Spectra of normal tissues can be attributed mainly to lipids whereas pathological tissue spectra are dominated by proteins. Principal components analysis (PCA) of the spectral data sets belonging to the four different categories showed that scores of factors differentiated between.

Item Type: Article
Uncontrolled Keywords: Raman spectroscopy, Principal components analysis, Oral cancer
Subjects: Dentistry > MCODS Manipal > Oral Medicine and Radiology
Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Surgical Oncology
Depositing User: KMC Manipal
Date Deposited: 29 Sep 2011 04:50
Last Modified: 29 Sep 2011 04:50
URI: http://eprints.manipal.edu/id/eprint/1416

Actions (login required)

View Item View Item