Effect of oral premedication on sub arachnoid block for elective lower limb surgeries

Monteiro, Ashma Dorothy (2014) Effect of oral premedication on sub arachnoid block for elective lower limb surgeries. International Journal of Health Sciences & Research, 4 (11). pp. 86-91. ISSN 2249-9571

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Objectives: To study the effect of premedication with oral clonidine on spinal anaesthesia with 0.5% hyperbaric bupivacaine. Method: 61 patients posted for elective lower limb surgeries were included in this study. They were randomly divided into 2 groups, Group 1 (OC) 30 patients received oral clonidine 2.5 mcg/kg prior to spinal anaesthesia with 3cc of 0.5 % hyperbaric bupivacaine. Group 2(C) 31 patients received plain 3 cc of 0.5 % hyperbaric bupivacaine. Statistical Methods: The statistical analysis was done using SPSS software Version 15. The analysis done included Mean and standard deviation, Fisher Exact test for association and Mann-Whitney U tests. Results: The age and weight distribution were similar in the two groups. The onset of motor blockade was seen to occur earlier in the intervention group compared to the control group (p=0.002).Moderate sedation was observed in all patients that received oral clonidine. There was a statistical significance between the two groups with respect to postoperative analgesia. The oral clonidine group showed a more stable haemodynamic profile in the postoperative period. Conclusion: Premedication with 2.5 mcg/kg of oral clonidine prior to spinal anaesthesia provides better postoperative analgesia, earlier onset of motor blockade and more sedation as compared to hyperbaric bupivacaine, with stable hemodynamics.

Item Type: Article
Uncontrolled Keywords: Oral clonidine; spinal anaesthesia; bupivacaine; postoperative analgesia.
Subjects: Departments at MU > Statistics
Depositing User: KMC Manipal
Date Deposited: 17 Jan 2015 06:41
Last Modified: 17 Jan 2015 06:41
URI: http://eprints.manipal.edu/id/eprint/141636

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