A review on response of immune system in spinal cord injury and therapeutic agents useful in treatment

Kasinathan, Narayanan and Vanathi, Meenashi B and Volety, Subrahmanyam Mallikarjuna and Rao, Josyula Venkata (2015) A review on response of immune system in spinal cord injury and therapeutic agents useful in treatment. Current Pharmaceutical Biotechnology, 16 (1). pp. 26-34.

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Abstract

Every year more than 12,000 people in US alone suffer from spinal cord injury. However, complete recovery of physical function is difficult due to multiple factors involved in disease progression. Currently available therapeutic regimens do not address all the factors concerned with the disease progression. The present review focuses mainly on the role of immune cells in progression of spinal cord injury and the drugs that target these immune cells. Literature search shows that inflammatory reactions and subsequent reactions that follow direct injury to spinal cord are sometimes responsible for the severity of the disease. Therefore, for design of proper treatment regimen a deep understanding in this area is required. Understanding the pathophysiology will help in creating delivery system that can target multiple factors involved in progression of spinal cord injury. A combination of various treatment strategies is required to reduce the disability in patients with spinal cord injury.

Item Type: Article
Uncontrolled Keywords: Autoimmunity; immune system; inflammation; natural compounds; spinal cord injury.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Depositing User: KMC Manipal
Date Deposited: 20 Jan 2015 09:59
Last Modified: 20 Jan 2015 09:59
URI: http://eprints.manipal.edu/id/eprint/141664

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